Fibrin associated large B-cell lymphoma accidentally identified in a breast implant capsule: a molecular report of a rare entity| Pathologica - Journal of the Italian Society of Anatomic Pathology and Diagnostic Cytopathology
Vol. 116: Issue 4 - August 2024
DOI: 10.32074/1591-951X-944
Case reports
Published: 2024-09-30
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Fibrin associated large B-cell lymphoma accidentally identified in a breast implant capsule: a molecular report of a rare entity

Division of Pathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
Division of Pathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Anatomic Pathology Unit, Department of Medical Biotechnology, University of Siena, Siena, Italy.
Anatomic Pathology Unit, Department of Medical Biotechnology, University of Siena, Siena, Italy.
Department of Oncology, Pisa University Hospital, Pisa, Italy.
Breast Centre AOUP, University Hospital of Pisa, Pisa, Italy.
Breast Centre AOUP, University Hospital of Pisa, Pisa, Italy.
Department of Clinical and Molecular Medicine Sapienza University, School of Medicine and Psychology Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy
Division of Pathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Anatomic Pathology Unit, Department of Medical Biotechnology, University of Siena, Siena, Italy.
Breast implant associated lymphoma Non-Hodgkin lymphoma Fibrin associated-large B cell lymphoma

Abstract

Breast implant-associated (BIA) lymphoma is a rare malignancy, typically originating from T-cells; however, few cases of diffuse large B-cell lymphoma (LBCL) have been recently described. These cases share major features: Epstein-Barr virus positivity and a favorable prognosis with surgical intervention alone, hinting at a potential link to fibrin-associated LBCL (FA-LBCL). This study presents the first case of BIA-FA-LBCL in Italy and one of the few assessed from a molecular standpoint so far. We identified two pathogenic mutations in DNMT3A and a variant of uncertain significance (VUS) in JAK2. These findings suggest that dysfunctional epigenetic mechanisms and constitutive activation of the JAK-STAT pathway may underpin BIA-FA-LBCL lymphomagenesis. Finally, we summarized all the previously reported cases in alignment with the updated WHO-HAEM5 classification, shedding further light on the nature of this new entity. This report highlights the rarity of BIA-FA-LBCL and underscores the importance of comprehensive capsule sampling and reporting to national databases for accurate characterization and management of these lymphomas. The study supports the classification of BIA-FA-LBCL within the spectrum of FA-LBCL, emphasizing the need for further research to elucidate its molecular underpinnings and improve clinical outcomes.

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Affiliations

$authorString->getOrcid() =>

$authorString->getFullName() => Cristian Scatena

$authorString->getUrl() =>

Cristian Scatena

Division of Pathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
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$authorString->getFullName() => Antonio Giuseppe Naccarato

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Antonio Giuseppe Naccarato

Division of Pathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
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$authorString->getFullName() => Margherita Vannucchi

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Margherita Vannucchi

Anatomic Pathology Unit, Department of Medical Biotechnology, University of Siena, Siena, Italy.
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$authorString->getFullName() => Maria Chiara Siciliano

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Maria Chiara Siciliano

Anatomic Pathology Unit, Department of Medical Biotechnology, University of Siena, Siena, Italy.
non esiste orcidID ""

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$authorString->getFullName() => Angelo Giovanni Bonadio

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Angelo Giovanni Bonadio

Department of Oncology, Pisa University Hospital, Pisa, Italy.
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$authorString->getFullName() => Livio Colizzi

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Livio Colizzi

Breast Centre AOUP, University Hospital of Pisa, Pisa, Italy.
non esiste orcidID ""

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$authorString->getFullName() => Matteo Ghilli

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Matteo Ghilli

Breast Centre AOUP, University Hospital of Pisa, Pisa, Italy.
non esiste orcidID ""

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$authorString->getFullName() => Arianna Di Napoli

$authorString->getUrl() =>

Arianna Di Napoli

Department of Clinical and Molecular Medicine Sapienza University, School of Medicine and Psychology Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy
non esiste orcidID ""

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$authorString->getFullName() => Giuseppe Nicolò Fanelli

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Giuseppe Nicolò Fanelli

Division of Pathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
non esiste orcidID ""

$authorString->getOrcid() =>

$authorString->getFullName() => Stefano Lazzi

$authorString->getUrl() =>

Stefano Lazzi

Anatomic Pathology Unit, Department of Medical Biotechnology, University of Siena, Siena, Italy.
non esiste orcidID ""

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright

© Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology , 2024

How to Cite

[1]
Scatena, C., Naccarato, A.G., Vannucchi, M., Siciliano, M.C., Bonadio, A.G., Colizzi, L., Ghilli, M., Di Napoli, A., Fanelli, G.N. and Lazzi, S. 2024. Fibrin associated large B-cell lymphoma accidentally identified in a breast implant capsule: a molecular report of a rare entity. Pathologica - Journal of the Italian Society of Anatomic Pathology and Diagnostic Cytopathology. 116, 4 (Sep. 2024), 242-248. DOI:https://doi.org/10.32074/1591-951X-944.
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