https://www.pathologica.it/ <p class="p1"> </p> <p class="p2"> </p> en-US <h2><strong>AUTHORSHIP STATEMENT FORM</strong></h2> <p><strong>AUTHORSHIP RESPONSIBILITY</strong></p> <p>(1) All authors participated sufficiently in the intellectual content, analysis of data (if applicable) and writing of the article, as defined by the criteria for authorship by the International Committee of Medical Journal Editors (http://www.icmje.org/). (2)&nbsp;The corresponding author certifies that the definitive version of the manuscript has been approved by all co-authors, as well as, by the director of the Institute or Department where the work has been carried out. (3) All persons who have made substantial contributions to the work reported in this manuscript (e.g., data collection, writing or editing assistance) but who do not fulfill the authorship criteria are named along with their specific contributions as an acknowledgement in the manuscript. 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According to articles 15-20 of the GDPR, any author may&nbsp;exercise specific rights, including the right to obtain access to personal data in an intelligible form, correct, update or cancel them.&nbsp;Authors will also have the right to obtain from the Publisher limitation of data processing, and may also oppose to data processing legitimate reasons.&nbsp;In the case that the author believes that processing of his/her own personal data infringes the of GDPR regulation, he/she has the right to make a complaint&nbsp;to the Supervisory Authority for the Protection of Personal Data according to art.&nbsp;77 of the GDPR. Controller of data processing, according to art.&nbsp;4.1.7 of the GDPR, is Mrs. Donatella Paoletti for Pacini Editore Srl, with registered office in 56121 Pisa, Italy, Via A Gherardesca n.&nbsp;1. To exercise the rights of GDPR referred to in paragraph 6 of the same article, you can address any request for information to the following e-mail:&nbsp;privacy@pacinieditore.it. For further information refer to the website:&nbsp;https://www.pathologica.it/about/privacy</p> <p><br> <strong>FINANCIAL DISCLOSURE.&nbsp;</strong>All authors must state any information that may be perceived as potential&nbsp;<em>conflict of interest</em>. All authors must disclose all their affiliations including any relevant personal or institutional financial involvement (employment by an industrial concern, consultancies, honoraria, speakers bureau, stock ownership or options, expert testimony, grants received or pending, membership on a standing advisory council or committee, a seat on the board of directors, or being publicly associated with a company or its products, royalties, donation of medical equipment, etc.) with any organization that to any author’s knowledge has a direct interest, particularly a financial interest, in the subject matter or materials discussed. This declaration will be treated by the Editor as confidential while the paper is under review, and will not be made known to Reviewers. &nbsp;Please indicate on the&nbsp;<strong>Authorship Statement Form</strong>&nbsp;whether or not you have or may have such a conflict of interest regarding the content of this article and is the nature of it.</p> <p><strong>COPYRIGHT TRANSFER AGREEMENT.&nbsp;</strong>(a) Authors assign to “Pathologica”, all copyright in and to the article, including but not limited to the right to publish, republish, transmit, sell, distribute and otherwise use the article in whole or in part, in electronic and print editions of the Journal and in derivative works throughout the world, in all languages and in all media of expression now known or later developed, and to license or permit others to do so. (b) The authors retain all proprietary rights, other than copyright, such as patent rights. The authors retain the right to reuse any portion of the work, without charge, in personal compilations or other publications consisting solely of the author(s’) own works, including the author(s’) personal web home page, and to make copies of all or part of the Work for the author(s’) use for lecture or classroom purposes. The corresponding author declares that any person named as co-author of the article is aware of the submission and has agreed to being so named. The corresponding author accepts responsibility for releasing this material on behalf of any and all co-authors. The corresponding author declares that statements and opinions given in the article are the expression of the authors. Responsibility for the content of the article rests upon the authors.</p> pathologica@pacinieditore.it (Mattia Barbareschi) pathologica@pacinieditore.it (Manuela Mori, Mara di Stefano) Sun, 30 Jun 2024 00:00:00 +0000 OJS 3.1.2.4 http://blogs.law.harvard.edu/tech/rss 60 https://www.pathologica.it/article/view/959 Massimo Barberis, Nicoletta Colombo, Nicoletta Cerana Copyright (c) 2024 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology http://creativecommons.org/licenses/by-nc-nd/4.0 https://www.pathologica.it/article/view/959 Sun, 30 Jun 2024 00:00:00 +0000 https://www.pathologica.it/article/view/980 <p class="p1">Melanoma of the external auditory canal (EAC) is particularly rare and poorly understood, with limited available data on management and survival. This systematic review aims to analyze existing data and provide insights into the management and prognosis the beginning of EAC melanoma. It is conducted using Pubmed and Scopus databases from the beginning to July 2023 and it follows the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines. Searches are performed using the search string “(melanoma) AND (external auditory canal)”.</p> <p class="p1">The review includes a total of 30 patients diagnosed with EAC melanoma, supplemented by an additional case from the authors’ clinical experience. The role of Breslow thickness as a determining factor for the choice of surgery remains inconclusive due to limited available data. Sentinel lymph node biopsy and adjuvant therapy are sparingly employed, indicating the need for standardized guidelines. Patients in the study demonstrate a 50% overall survival rate at 5 years.<span class="Apple-converted-space">&nbsp;</span></p> <p class="p1">EAC Melanoma is a rare and aggressive malignancy with limited therapeutic guidelines. Surgical interventions, including wide local excision and lateral temporal bone resection, are the primary treatment options for patients without distant metastases.<span class="Apple-converted-space">&nbsp;</span></p> Marco Demattè, Carlotta Liberale, Anna Bonsembiante, Marco Bottazzoli, Alessandro Ioppi, Alessandro La Boria, Alessandra Marcantoni, Pietro Perotti, Raffaele Rosaia, Vittorio Torta, Maria Grazia Zorzi, Ottavio Piccin Copyright (c) 2024 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology http://creativecommons.org/licenses/by-nc-nd/4.0 https://www.pathologica.it/article/view/980 Sun, 30 Jun 2024 00:00:00 +0000 https://www.pathologica.it/article/view/911 <p class="p1">Secondary neoplastic lesions in lymph nodes are predominantly metastases from solid tumors, whereas primary lymph node hemangiomas are exceptionally uncommon, with only 24 well-documented cases in the literature. Histologically, they are characterized by endothelial cells that may appear flattened or enlarged, with variable vascular density, and the presence of stromal elements. Notably, the concurrent presence of a primary hemangioma and a metastasis from breast cancer – the latter being the most prevalent secondary lesion in axillary lymph nodes – represents an unprecedented observation. The unique case presented herein underscores the exceptional rarity of primary lymph node hemangiomas and demonstrates for the first time their possible coexistence with breast cancer metastasis within the same axillary lymph node. In sharing and discussing this case study, we pay homage to Professor Juan Rosai, whose work in redefining rare and complex diagnoses continues to enlighten our understanding of lymph node vascular lesions.</p> Mariia Ivanova, Marianna D'Ercole, Francesca Maria Porta, Benedetta Di Venosa, Chiara Frascarelli, Camillo Di Bella, Fabio Pagni, Elena Guerini-Rocco, Nicola Fusco Copyright (c) 2024 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology http://creativecommons.org/licenses/by-nc-nd/4.0 https://www.pathologica.it/article/view/911 Sun, 30 Jun 2024 00:00:00 +0000 https://www.pathologica.it/article/view/922 <p class="p1">Hepatocellular carcinoma typically metastasizes within the liver and may involve extrahepatic sites such as the lungs, adrenal glands, and bones at advanced stages. However, hepatocellular carcinoma metastasis to the thyroid is very uncommon and tumor-to-tumor metastasis from a hepatocellular cancer to a thyroid neoplasm is extremely rare. In this report, we present a case of a 70-year-old man with a hepatocellular carcinoma metastasizing to oncocytic thyroid carcinoma, emphasizing the importance of clinical history and of a multidisciplinary approach, as well as the usefulness of site-specific immunohistochemical markers, in diagnosing and managing cases of Rosai’s metastasis, especially when donor and recipient neoplasms share similar histologic features.</p> Marcello Maestri, Ottavia Cicerone, Alessia Messina, Anna Gallotti, Salvatore Corallo, Simone Mauramati, Pietro Canzi, Giacomo Fiandrino, Marco Paulli, Alessandro Vanoli Copyright (c) 2024 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology http://creativecommons.org/licenses/by-nc-nd/4.0 https://www.pathologica.it/article/view/922 Sun, 30 Jun 2024 00:00:00 +0000 https://www.pathologica.it/article/view/955 <p class="p1">The 5th WHO classification of thoracic tumours includes thoracic SMARCA4-deficient undifferentiated tumour (SMARCA4-UT) among the “other epithelial tumours of the lung” chapter. Herein, we present a case of undifferentiated thoracic neoplasm with retention of SMARCA4 expression, lack of NUT fusion protein and loss of SMARCB1/INI1 expression. After presenting the clinical and pathological features of the tumour, we carried out a review of the literature on the same topic. Albeit very rare, we believe this entity should be included in the heterogeneous group of undifferentiated neoplasms of the thorax.</p> Moreno Zagni, Alessandro Marando, Mariachiara Negrelli, Calogero Lauricella, Valentina Motta, Giulia Paglino, Silvio Veronese, Emanuele Valtorta, Emanuela Bonoldi, Giuseppe Pelosi Copyright (c) 2024 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology http://creativecommons.org/licenses/by-nc-nd/4.0 https://www.pathologica.it/article/view/955 Sun, 30 Jun 2024 00:00:00 +0000 https://www.pathologica.it/article/view/970 <p class="p1">Embryonal tumors with multilayered rosettes (ETMR) are highly aggressive and therapy-resistant pediatric central nervous system (CNS) tumors that have three histological patters: embryonal tumor with abundant neuropil and true rosettes, ependymoblastoma, and medulloepithelioma. We present a case of ETMR in an 18-year-old woman with DICER1 syndrome. This report confirms the important role of DNA-methylation analysis in the classification of CNS embryonal tumors and the importance of investigating somatic and germline <em>DICER1</em> mutations in all CNS embryonal tumors.</p> María Concepción Campos Mármol, María Aguado, Teresa Ramón y Cajal, Alberto Gallardo, Luis Catasús, Allan Gonzalez, Jorge Eliecer Méndez, Adriana Lasa, Montse Arumi, Oscar Gallego, Josep Balart, Fernando Muñoz, Andreas von Deimling, Felix K.F. Kommoss, Iñigo Espinosa Copyright (c) 2024 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology http://creativecommons.org/licenses/by-nc-nd/4.0 https://www.pathologica.it/article/view/970 Sun, 30 Jun 2024 00:00:00 +0000 https://www.pathologica.it/article/view/974 <p class="p1">A corded and hyalinized pattern has been described in endometrial endometrioid carcinoma. Herein, we describe a clinicopathological and molecular analysis of the first reported case of endometrial serous carcinoma with a corded and hyalinized pattern.</p> <p class="p1">A 64-year-old woman underwent hysterectomy and bilateral salpingo-oophorectomy due to a 5.5 cm endometrial lesion. Histologically, the tumor was composed of a minor (20%) serous carcinoma component and a predominant corded component embedded in a hyaline-to-myxoid matrix. This component showed diffuse and strong p53 and p16 expression, heterogeneous positivity for epithelial markers and WT1, focal positivity for estrogen and progesterone receptors, retained MMR, SMARCA4/BRG1, and SMARCB1/INI1 expression, and negativity for smooth muscle, germ cell, sex cord, neuroendocrine, endothelial, and melanocytic markers and GATA3. Next-generation sequencing showed a mutation of uncertain significance in <em>APC</em> and no mutations in <em>MLH1, MSH2, MSH6, PMS2, MUTYH, POLE, POLD1, EPCAM</em>, or <em>CTNNB1</em>. The patient had a recurrence on the vaginal stump after 15 months.<span class="Apple-converted-space">&nbsp;</span></p> <p class="p1">In conclusion, endometrial serous carcinoma can show a corded and hyalinized pattern, which may represent a diagnostic challenge.</p> Antonio Travaglino, Angela Santoro, Damiano Arciuolo, Giulia Scaglione, Antonio Raffone, Alessia Piermattei, Maria Elisabetta Onori, Angelo Minucci, Luigi Pedone Anchora, Francesco Fanfani, Gian Franco Zannoni Copyright (c) 2024 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology http://creativecommons.org/licenses/by-nc-nd/4.0 https://www.pathologica.it/article/view/974 Sun, 30 Jun 2024 00:00:00 +0000 https://www.pathologica.it/article/view/956 <p class="p1"><span class="s1">The routine use of iodine tincture in medicine represents a turning point in the history of surgical procedures. It was the Istrian doctor Antonio Grossich (1849-1926) who first defined and applied the best formula and demonstrated to the world its superiority over other antiseptics. Although his was a life guided by medicine and the steadfast translation of his political ideals into practice, Grossich’s achievements were somewhat obscured by his active involvement in the Istrian irredentism of the first decades of the </span><span class="Y2IQFc" lang="en">twentieth </span><span class="s1">century.<span class="Apple-converted-space">&nbsp;</span></span></p> Carlo Patriarca, Carlo Alfredo Clerici, Maura Massimino Copyright (c) 2024 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology http://creativecommons.org/licenses/by-nc-nd/4.0 https://www.pathologica.it/article/view/956 Sun, 30 Jun 2024 00:00:00 +0000 https://www.pathologica.it/article/view/982 <p class="p1">In 2023 an important anniversary took place. It regards Virchow’s report on the Upper Silesia epidemic typhus, which was associated with the death of numerous Polish peasants. It is also the starting point of Virchow’s political career and fight against antisemitism, which has reached fearful levels in academia. Antisemitism is not new, but the recrudescence following the October 7^th massacre of Jewish and not-Jewish people is appalling and recalls Virchow’s vehemence of the past a few decades before the Nazi extermination of the Shoah during the World War II.</p> Consolato Maria Sergi Copyright (c) 2024 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology http://creativecommons.org/licenses/by-nc-nd/4.0 https://www.pathologica.it/article/view/982 Sun, 30 Jun 2024 00:00:00 +0000 https://www.pathologica.it/article/view/962 Simone Mauramati, Fabio Pedretti, Irene Herman, Giuseppe Trisolini, Alberto Luchena, Rebecca Gelli, Emanuele Robiolio, Marta Minuti, Maria Vittoria Veneroni, Giulia Bertino, Monica Feltri, Gioacchino D'Ambrosio, Marco Benazzo, Patrizia Morbini Copyright (c) 2024 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology http://creativecommons.org/licenses/by-nc-nd/4.0 https://www.pathologica.it/article/view/962 Sun, 30 Jun 2024 00:00:00 +0000